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TEAM OVERVIEW & PIS
Dr. Lee, Hyojin (이효진)
- E-mailhyojinlee@kist.re.kr
Our group focuses on “synthesis smart nanomaterials for diagnosis and treatment of diseases”. We are developing nanoconstructs as a new type of drug delivery system since their “cargo” can be released by changes in environmental factors including ionic strength. Also. We are interested in bio-sensor surface modification to introduce the function that can allow to recognition of specific biomarkers in clinical sample for determination of diseases.
바이오 나노구조체 연구실은 생체 친화적 나노재료를 합성하여 질병을 진단하고 치료하는 연구에 중점을 두고 있습니다. 나노재료의 기초 특성을 조절하여 선택적으로 세포 내에 물질을 전달하는 신개념의 나노전달체를 개발하고 있으며, 나노물질 표면개질을 통한 바이오리셉터 도입방법 개발을 통해 바이오센서가 특정 질병인자를 인식할 수 있도록 기능을 부여하는 연구를 진행하고 있습니다.
Academic Career
- 2004 ~ 2007
B.S. in Bioengineering, Summa cum laude, Catholic University of Korea
- 2008 ~ 2012
Ph.D. in Bio Chemistry, Department of chemistry, Seoul National University
- 2012 ~ 2013
Post-doctoral fellowship, Division of Chemistry and Molecular Engineering, Brain Korea 21, Seoul National University
- 2013 ~ 2015
Post-doctoral fellowship, Department of Chemistry, Northwestern University
- 2015 ~ 2016
Post-doctoral fellowship, Korea Institute of Science and Technology (KIST)
- 2016 ~ 2020
President Post-doctoral fellowship, Korea Institute of Science and Technology (KIST)
- 2018 ~ 2022
Senior Researcher, Biomedical Research Institute, Korea Institute of Science and Technology (KIST)
- 2019 ~
Associate Professor, KIST School, Korea Institute of Science and Technology (KIST)
- 2023 ~
Principal Researcher, Biomaterials Research Center, KIST, Korea Institute of Science and Technology (KIST)
Representative PapersAll the other papers
* : Corresponding Author, #: equal contribution
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1. Seongchan Kim,You Kyeong Jeong,Chang Sik Cho,Seokhoon Lee,Chang Ho Sohn,Jeong Hun Kim,Youngdo Jeong,Dong Hyun Jo*,Sangsu Bae*,and Hyojin Lee*, "Enhancement of Gene Editing and Base Editing with Therapeutic Ribonucleoproteins through In Vivo Delivery Based on Absorptive Silica Nanoconstruct" Advanced Healthcare Materials (2023)
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2. Seongchan Kim*, I-Seon Lee, Hyojin Lee*, “Combination Treatment of Hepatitis C Virus-Associated Hepatocellular Carcinoma by Simultaneously Blocking Genes in Multiple Organelles via Functionally Engineered Graphene Oxide ”Chemical Engineering Journal , (2023) 452, 15
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3. WonseokChoi, JaehongKey, InchanYoun, HyojinLee*, SungminHan * , “Cavitation-assisted sonothrombolysis by asymmetrical nanostars for accelerated thrombolysis” J. Controlled Release, (2022) 350.
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4. Sangmin Song, Seung-Hoon Um, Jaeho Park, Inho Ha, Jaehong Lee, Seongchan Kim, Hyojin Lee, Cheol-Hong Cheon, Seung Hwan Ko*, Yu-Chan Kim*, Hojeong Jeon* , “Rapid Synthesis of Multifunctional Apatite via the Laser-Induced Hydrothermal Process” ACS Nano, (2022) 16, 8, 12840-12951
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5. Woongsun Choi, Eunhye Park, Seojin Bae, Kyung-Hak Choi, Sangeun Han, Kuk-Hui Son, Do Young Lee, Il-Joo Cho, Hyejeong Seong, Kyo Seon Hwang, Jwa-Min Nam, Jungkyu Choi*, Hyojin Lee*, Nakwon Choi*, “Multiplex SNP Genotyping Using SWITCH: Sequence-Specific Nanoparticle with Interpretative Toehold-Mediated Sequence Decoding in Hydrogel” Small, (2022) 18, 2105538.
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6. Seongchan Kim, Taegon Oh, Hyojin Lee*, and Jwa-Min Nam*, “Trends and perspectives in bio- and eco-friendly sustainable nanomaterial delivery systems through biological barriers” Materials Chemistry Frontiers, (2022) published online.
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7. Seongchan Kim, Shin Young Kim, Seung Joon Rho, Seung Hoon Kim, So Hyang Song, Chi Hong Kim, Hyojin Lee*, and Sung Kyoung Kim*, “Biocompatible N-acetyl-nanoconstruct Alleviates Lipopolysaccharide-induced Acute Lung Injury In Vivo” Scientific Reports, (2021) in press
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8. Hyojin Lee*, Seongchan Kim, Kyeong Seob Hwang, Nu Ri Lim, Han Bin Oh, Il-Joo Cho, Jongbaeg Kim*, Ki Hun Kim*, Hong Nam Kim*, “Effect of carbon nanomaterial dimension on the functional activity and degeneration of neurons” Biomaterials, (2021) 279, 121232
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9. Adaptive self-healing electronic epineurium for chronic bidirectional neural interfaces” K.I Song, H. Seo, D. Seong, S. Kim, K Yu, Y. Kim, J Kim, S. Kwon, H. Han, I Yoon*, H. Lee* and D Son*, Nature Communications (2020).
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10. “Non-invasive Molecular Barcode Assay for Diagnosis of Sex Hormones Correlated with Precocious Puberty” H.Lee, KH Kim and K.H. Lee, Sensors and Actuators B Chemistry (2019).
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11. “High Throughput Differential Identification of TMPRSS2-ERG Fusion Genes in Prostate Cancer Patient Urine” H.Lee, D.Lee, J. Park, S. Peter, and K.H. Lee, Biomaterials (2017).
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12. “Transparent, Nanoporous, and Transferable Membrane-Based Cell–Cell Paracrine Signaling Assay” Y. Jang†, H.Lee†, K. Char and J.-M. Nam Advanced Materials (2015).
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13. “Bio-Barcode Gel Assay for microRNA” H. Lee, J. Park and J.-M. Nam, Nature Communications (2014).
Korea Institute of Science and Technology (KIST) L1457 Hwarangno 14-gil 5 Seongbuk-gu Seoul, 136-791 Republic of Korea
TEL+82-2-958-5375FAX+82-2-958-5449
